Data/hora: 10/06/2024 16:02:42

Provedor de dados: | 60
País: | Brazil
Título: | Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
Autores: | Cazedey,Edith Cristina Laignier; Carvalho,Flávia Chiva; Fiorentino,Flávia Angélica Másquio; Gremião,Maria Palmira Daflon; Salgado,Hérida Regina Nunes.
Data: | 2009-12-01
Ano: | 2009
Palavras-chave: | Animal experimentation/alternative methods in vitro; Experiments/in vitro methods; Corrositex®/in vitro method/experiments; BCOP/in vitro method/experiments; HET-CAM/in vitro method/experiments.
Resumo: | Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can often be subjective. Protests calling for animal protection have questioned the effectiveness of in vivo tests and suggest the introduction of alternative, in vitro methods. International organizations, such as the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Institute of Health (NIH), the Organization for Economic Co-operation and Development (OECD), that regulate and develop new alternative animal models, have indicated the running of preliminary assays and execution of sequential tests, which consider physical-chemical properties and data of in vitro assays, before performing in vivo studies. Towards this background, the objective of the present article was to select promising alternative methods such as Corrositex®, BCOP and HET-CAM, intended to refine or replace the use of animals and reduce their suffering.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400021
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502009000400021
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.45 n.4 2009
Fonte: | info:eu-repo/semantics/openAccess