Data/hora: 09/06/2024 04:41:38

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Effects of Cymbopogon winterianus Jowitt ex Bor essential oil on the growth and morphogenesis of Trichophyton mentagrophytes	
Autores: 	Pereira,Fillipe de Oliveira; Wanderley,Paulo Alves; Viana,Fernando Antônio Cavalcanti; Lima,Rita Baltazar de; Sousa,Frederico Barbosa de; Santos,Sócrates Golzio dos; Lima,Edeltrudes de Oliveira.	
Data: 	2011-03-01	
Ano: 	2011	
Palavras-chave: 	Trichophyton mentagrophytes/mycology; Dermatophytosis Cymbopogon winterianus/essential oil; Dermatophytosis Cymbopogon winterianus/antifungal activity; Dermatophytes.	
Resumo: 	Trichophyton mentagrophytes is a fungus causative agent of dermatophytosis, affecting humans worldwide. This has driven the search for products for the treatment of these infections. Accordingly, the aim of this study was to investigate the antifungal activity of the Cymbopogon winterianus essential oil against T. mentagrophytes. The antifungal tests consisted of antifungal screening, determination of MIC and MFC, analysis of the essential oil's effects on mycelial growth, germination of fungal spores, fungal viability, morphogenesis, cell wall (test with sorbitol) and cell membrane (cell leakage test) of T. mentagrophytes. Upon screening, the oil inhibited all strains, with zones of growth inhibition of 24-28 mm in diameter. The MIC was 312 μg/mL and CFM was 2500 μg/mL for almost all the strains tested. There were morphological changes in the conidia group, form and pigmentation of hyphae. The antifungal action of the product does not involve the cell wall and its action may involve the fungal plasma membrane. It is concluded that C. winterianus essential oil constitutes a potential antifungal product, especially for the treatment of dermatophytosis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100018	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502011000100018	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.47 n.1 2011	
Fonte: 	info:eu-repo/semantics/openAccess