Data/hora: 16/06/2024 06:27:17

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy	
Autores: 	Pierre,Maria Bernadete Riemma; Lopez,Renata Fonseca Vianna; Bentley,Maria Vitória Lopes Badra.	
Data: 	2009-03-01	
Ano: 	2009	
Palavras-chave: 	5-aminolevulinic acid; Ceramide 2; In vitro/Skin permeation; In vitro/Skin retention; Photodynamic therapy.	
Resumo: 	Photodynamic therapy (PDT) based on topical 5-aminolevulinic acid (5-ALA), an endogenous precursor of protoporphyrin, is an interesting approach for the treatment of skin cancer. However, 5-ALA is a hydrophilic molecule and such a characteristic limits its appropriate cutaneous penetration and retention. In this way, more lipophilic molecules, such as esterified 5-ALA derivatives, have been under investigation in order to improve the skin penetration of this molecule. Drug formulation can also alter 5-ALA skin penetration. Therefore, the aim of this work was to study the influence of ceramide 2 - the main lipid of the SC- on the cutaneous delivery of 5-ALA and its ester derivatives in vitro, using Franz diffusion cell. The skin permeation of all studied drugs was decreased in the presence of ceramide, representing a desirable characteristic in order to avoid the risk of systemic side effects. Nevertheless, the SC and [epidermis + dermis] retention after 16 h has also been decreased in the presence of ceramide, as compared to control. In conclusion, ceramide was not a good adjuvant, meaning that research of other vehicles could be useful to improve cutaneous delivery of 5-ALA.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100013	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502009000100013	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.45 n.1 2009	
Fonte: 	info:eu-repo/semantics/openAccess