Data/hora: 13/06/2024 08:12:31

Provedor de dados: | Brazilian Journal of Pharmaceutical Sciences
País: | Brazil
Título: | Isolation of flavonoids from Anemopaegma arvense (Vell) Stellf. ex de Souza and their antifungal activity against Trichophyton rubrum
Autores: | Costanzo,Camila Di Giovane; Fernandes,Vanessa Colnaghi; Zingaretti,Sônia; Beleboni,Rene Oliveira; Pereira,Ana Maria Soares; Marins,Mozart; Taleb-Contini,Sílvia Helena; Pereira,Paulo Sérgio; Fachin,Ana Lúcia.
Data: | 2013-09-01
Ano: | 2013
Palavras-chave: | Bignoniaceae; Anemopaegma arvense/phytochemistry; Catuaba/phytochemistry; Flavonoids/antifungal activity; Plant extract/evaluation.
Resumo: | Anemopaegma arvense (Vell) Stellf. ex de Souza belongs to the family Bignoniaceae, and is popularly known as catuaba. To evaluate the cytotoxic and antimicrobial activity of A. arvense, fraction F3 and flavonoids 1 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside) (rutin) and flavonoid 2 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside) were isolated from the leaves of this plant. Fraction F3 and flavonoids 1 and 2 exhibited no antibacterial activity. Furthermore, no cytotoxic activity of fraction 3 or flavonoids 1 and 2 was observed against the tumor cells tested. However, analysis of the antifungal activity of flavonoids 1 and 2 revealed minimum inhibitory concentrations of 0.5 and 0.25 mg/mL, respectively, against the Trichophyton rubrum strains tested (wild type and mutant). This study demonstrates for the first time the antifungal activity of isolated flavonoids, validating the same activity for A. arvense.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300017
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502013000300017
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.49 n.3 2013
Fonte: | info:eu-repo/semantics/openAccess