Data/hora: 13/06/2024 00:36:51

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Polymeric micelles and molecular modeling applied to the development of radiopharmaceuticals	
Autores: 	Grallert,Sibila Roberta Marques; Rangel-Yagui,Carlota de Oliveira; Pasqualoto,Kerly Fernanda Mesquita; Tavares,Leoberto Costa.	
Data: 	2012-03-01	
Ano: 	2012	
Palavras-chave: 	Radiopharmaceuticals/development; Polymeric micelles/diagnostic application; Radioisotopes; Imaging diagnostic agents; Diagnostic techniques.	
Resumo: 	Micelles composed of amphiphilic copolymers linked to a radioactive element are used in nuclear medicine predominantly as a diagnostic application. A relevant advantage of polymeric micelles in aqueous solution is their resulting particle size, which can vary from 10 to 100 nm in diameter. In this review, polymeric micelles labeled with radioisotopes including technetium (99mTc) and indium (111In), and their clinical applications for several diagnostic techniques, such as single photon emission computed tomography (SPECT), gamma-scintigraphy, and nuclear magnetic resonance (NMR), were discussed. Also, micelle use primarily for the diagnosis of lymphatic ducts and sentinel lymph nodes received special attention. Notably, the employment of these diagnostic techniques can be considered a significant tool for functionally exploring body systems as well as investigating molecular pathways involved in the disease process. The use of molecular modeling methodologies and computer-aided drug design strategies can also yield valuable information for the rational design and development of novel radiopharmaceuticals.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100002	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502012000100002	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.48 n.1 2012	
Fonte: 	info:eu-repo/semantics/openAccess