Data/hora: 16/06/2024 06:28:50

Provedor de dados: | 60
País: | Brazil
Título: | Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata
Autores: | García Delgado,Neivys; Frías Vázquez,Ana Iris; Cabrera Sánchez,Hiran; Soto del Valle,Roberto Menéndez; Sierra Gómez,Yusvel; Suárez Alfonso,Ana María.
Data: | 2013-03-01
Ano: | 2013
Palavras-chave: | Dichotomaria obtusata/pharmacognosy; Dichotomaria obtusata/anti-inflammatory activity; Dichotomaria obtusata/antinociceptive activity; Mouse ear edema test; Writhing test.
Resumo: | The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87µg/ear, while intraperitoneal administration presented a moderate activity. The extract did not inhibit phospholipase A2 activity. In the writhing test, the intraperitoneal administration of the extract showed a strong antinociceptive activity (80.2%), while the oral route showed a lower efficacy. In conclusion, this study demonstrated the anti-inflammatory and antinociceptive effects of methanol extract of D. obtusata in experimental models, suggesting its therapeutic potential in the treatment of peripheral painful and/or inflammatory pathologies.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100008
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502013000100008
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.49 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess