Data/hora: 10/06/2024 11:57:45

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Stability-indicating capillary zone electrophoresis assay for the analysis of linezolid in tablets	
Autores: 	Oliveira,Cristiani Lopes Capistrano Gonçalves de; Salgado,Hérida Regina Nunes; Moraes,Maria de Lourdes Leite.	
Data: 	2018-01-01	
Ano: 	2018	
Palavras-chave: 	Capillary-electrophoresis/assay; Linezolid/tablets/stability; Pharmaceutical-drugs.	
Resumo: 	A simple and fast alternative methodology using capillary zone electrophoresis (CZE) to analyze linezolid and its cationic photodegradation products in tablets has been developed. The separation was carried out on fused silica capillary and conducted using 100 mM formic acid (pH 3.0) and by applying 30 KV voltage. Detection was performed at UV 254 nm. The optimized method was validated in terms of linearity, limits of detection and quantification, precision (repeatability), stability studies (selectivity) and accuracy. Good linearity (8-20 mg L-1) was obtained and the limit of detection was 0.95 mg L-1. The greatest advantages of the CZE method were the rapid set-up of instrumentation and capillary equilibration, short analysis time (12 min), low running cost and low waste generation. The method showed good stability in determining linezolid submitted to degradation by light and to a climatic chamber and can be used as an alternative for evaluation in stability studies of linezolid in tablets, as well as for the analysis of the drug in raw materials and finished products.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400621	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/s2175-97902018000417585	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.54 n.4 2018	
Fonte: 	info:eu-repo/semantics/openAccess