Data/hora: 04/06/2024 19:18:11

Provedor de dados: | 62
País: | Brazil
Título: | Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats
Autores: | MEDEIROS,Rosane Maria Trindade de; GÓRNIAK,Silvana Lima; GUERRA,José Luis.
Data: | 1999-01-01
Ano: | 1999
Palavras-chave: | Milk; Pyrrolizidine alkaloids; Crotalaria spectabilis; Poisoning.
Resumo: | Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental group showed significantly higher (p&lt;0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p&lt;0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95961999000200008
Editor: | Faculdade de Medicina Veterinária e Zootecnia / Universidade de São Paulo
Relação: | 10.1590/S1413-95961999000200008
Formato: | text/html
Fonte: | Brazilian Journal of Veterinary Research and Animal Science  v.36 n.2 1999
Fonte: | info:eu-repo/semantics/openAccess