Data/hora: 06/06/2024 04:26:21

Provedor de dados: | 62
País: | Brazil
Título: | Role of previous stimulation on the neutrophil migration protects against the lethal effect of Salmonella typhimurium
Autores: | MORAES,Flávio Ruas de; KLEIN Jr.,Manoel Henrique; MORAES,Julieta Rodini Engrácia de.
Data: | 2000-01-01
Ano: | 2000
Palavras-chave: | Migration; Neutrophils; Salmonella typhimurium; Peritonitis; Septicemia; Phagocytosis.
Resumo: | The intraperitoneal inoculation of 3.8 x 10(9) CFU of alive Salmonella typhimurium caused 100% mortality in rats. In these animals a small number of neutrophils migrated to the peritoneal cavity. The intraperitoneal inoculation of the animals with thioglycollate (Tg, 90 mg), carrageenin (Cg, 500 mu g), or killed S. typhimurium (KS, 1.9 x 10(9) CFU) 24 hours before challenge with alive S. typhimurium caused a significant neutrophil migration to the peritoneal cavity (determined 6 hours after challenge) and protected the animals against the lethal effect of the bacteria at a rate of 50%, 83% and 80%, respectively. However, similar treatment of the animals with brain heart infusion broth (BHI, S. typhimurium grout medium) protected the animals by only 23%. The migrating neutrophils in these animals represented less than 10% of those observed with other treatments. The phagocytosis activity was not associated with the survival rate as this activity was 2 times higher in the KS group than in the Tg and Cg groups, and the survival rate in this group was similar to that observed in Cg. These results suggest that the increase of neutrophil migration to the infectious site is an important factor associated with protection of the animals against the lethal effect of the bacterial infection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962000000100002
Editor: | Faculdade de Medicina Veterinária e Zootecnia / Universidade de São Paulo
Relação: | 10.1590/S1413-95962000000100002
Formato: | text/html
Fonte: | Brazilian Journal of Veterinary Research and Animal Science  v.37 n.1 2000
Fonte: | info:eu-repo/semantics/openAccess