Data/hora: 11/06/2024 19:04:04

Provedor de dados: | 64
País: | Brazil
Título: | Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
Autores: | Paiva,Rojane de Oliveira; Kneipp,Lucimar Ferreira; Goular,Carla Marins; Albuquerque,Mariana Almeida; Echevarria,Aurea.
Data: | 2014-12-01
Ano: | 2014
Palavras-chave: | Aspergillus; Fusarium; Mycotoxicology; Thiosemicarbazones.
Resumo: | Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001
Editor: | Editora da Universidade Federal de Lavras
Relação: | 10.1590/S1413-70542014000600001
Formato: | text/html
Fonte: | Ciência e Agrotecnologia  v.38 n.6 2014
Fonte: | info:eu-repo/semantics/openAccess