Data/hora: 09/06/2024 06:10:32

Provedor de dados: | Ciência Rural
País: | Brazil
Título: | Development and maturation of the lung in fetuses of  Galea spixii and expression of markers
Autores: | Favaron,Phelipe Oliveira; Oliveira,Moacir Franco de; Borghesi,Jéssica; Anunciação,Adriana Raquel de Almeida; Miglino,Maria Angelica.
Data: | 2016-09-01
Ano: | 2016
Palavras-chave: | Respiratory system; Alveoli; Morphology; Rodent; Experimental model.
Resumo: | ABSTRACT: The aim of this research was to study the development of the lung in  Galea spixii , by gross anatomy, histological analysis and immunohistochemical techniques. Totally, 8 fetuses were used and allocated into three groups of age: Group I (33-35 days), Group II (38-40 days), and Group III (43-45 days) with given crown-rump - CR lenghts. According to the gross morphology, there were no differences in relation to the lung morphology among groups. In relation to lung maturation, the Group I showed early formation of the bronchi and bronchioles, which were richly surrounded by mesenchyme and small blood vessels, typical features of the pseudoglandular stage. Individuals from Group II showed higher amounts of tubular formations in the lung parenchyma and reduced mesenchyme, reaching the canalicular stage. The lung from individuals of the Group III was completely formed, reaching the alveolar phase. In the immunohistochemical analysis, the lung of individuals from both Groups I and II were positive for Pcna, Oct-4, and VEGF. In contrast, there was not labbeling on samples from Group III. Thus, the G. spixii lung anatomy resembles the agouti ( Dasyprocta sp.) lung, in relation to the number of lobes and fissures. In regard to the lung development, G. spixii showed more similarity with the human fetal lung, since both are born in the stage of the alveolar phase, different to other rodent species.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000901635
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/0103-8478cr20150711
Formato: | text/html
Fonte: | Ciência Rural  v.46 n.9 2016
Fonte: | info:eu-repo/semantics/openAccess