Data/hora: 13/06/2024 21:15:01

Provedor de dados: | 65
País: | Brazil
Título: | Multi-drug resistance gene (MDR1) and opioid analgesia in horses
Autores: | Natalini,Cláudio Corrêa; Cunha,Anderson Fávaro da; Linardi,Renata Lehn.
Data: | 2006-02-01
Ano: | 2006
Palavras-chave: | Molecular biology; Opioids; Equine; Gene; MDR1; ABCB1; Analgesia.
Resumo: | Opioid absorption in the intestinal tract as well as its effects in the central nervous system is modulated by the P-glycoprotein (P-gp) encoded in the Multi-drug Resistance gene (MDR1) also named ATP-binding cassete, subfamily B, member 1 (ABCB1). This MDR1 gene acts as a selective pump. The expression of this protein in humans and rodents inhibits cellular uptake of substrate opioids. The presence of the intestinal iso-enzyme CYP3A4 associated with MDR1 gene decreases the opioid analgesic activity due to an increase in intestinal metabolism, with a predicted intestinal first pass extraction around 20% which significantly influences the oral availability of opioids. In the central nervous system, P-gp expression decreases opioid neuronal uptake diminishing the analgesic effects. It is unknown if horses have the MDR1 gene and P-gp and what are the effects on opioid absorption, metabolism, and analgesia. Identifying the MDR1 gene and P-gp status in horses is of great importance in order to better understand opioid pharmacologic effects in horses.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100055
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/S0103-84782006000100055
Formato: | text/html
Fonte: | Ciência Rural  v.36 n.1 2006
Fonte: | info:eu-repo/semantics/openAccess