Data/hora: 03/06/2024 17:20:18

Provedor de dados: 	65	
País: 	Brazil	
Título: 	Chronic liver disease in cattle associated with ingestion of  Brachiaria spp.	
Autores: 	Faccin,Tatiane Cargnin; Kommers,Glaucia Denise; Galiza,Glauco José Nogueira de; Pupin,Rayane Chitolina; Madureira,Renata Cunha; Lemos,Ricardo Antônio Amaral de.	
Data: 	2016-11-01	
Ano: 	2016	
Palavras-chave: 	Slaughtered bovines; Fibrosis; Liver atrophy; Foamy macrophages.	
Resumo: 	ABSTRACT: One hundred and ninety livers condemned due to chronic disease (fibrosis) were evaluated in a bovine slaughterhouse over 12 months. Hepatic lymph nodes were also examined while still attached to livers. The major macroscopic lesion observed in the livers was moderate to severe atrophy of the left lobe associated with compensatory hypertrophy of the right lobe. Histologically, the main changes corresponded to sites of macroscopic lesions, and fibrosis was observed in all livers, along with bile duct hyperplasia and neovascularization. Masson's trichrome stain highlighted the fibrous connective tissue. Most of the livers analyzed had macrophages with foamy cytoplasm and a peripheral nucleus that infiltrated fibrotic areas. Immunohistochemistry (IHC) for macrophages with monoclonal antibody clone MAC 387 revealed that the cytoplasm of the foamy macrophages of the liver and of the hepatic lymph nodes were positively immunostained. These cells are frequently associated to the consumption of grasses of the genus Brachiaria. Although the liver gross lesions described in this study have not been previously reported in animals consuming Brachiaria , the associated changes observed histologically, such as fibrosis and infiltration of foamy macrophages, showed a new form of chronic liver disease probably associated with the consumption of this forage. The IHC technique was important to prove that the foam cells observed are macrophages.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001102036	
Editor: 	Universidade Federal de Santa Maria	
Relação: 	10.1590/0103-8478cr20160297	
Formato: 	text/html	
Fonte: 	Ciência Rural  v.46 n.11 2016	
Fonte: 	info:eu-repo/semantics/openAccess