Data/hora: 03/06/2024 05:03:43

Provedor de dados: | 65
País: | Brazil
Título: | Identification of multi-drug resistance gene (MDR1) in equine ileum
Autores: | Natalini,Cláudio Corrêa; Linardi,Renata Lehn.
Data: | 2006-02-01
Ano: | 2006
Palavras-chave: | Molecular biology; Opioids; Equine; Gene; MDR1; ABCB1.
Resumo: | P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/S0103-84782006000100048
Formato: | text/html
Fonte: | Ciência Rural  v.36 n.1 2006
Fonte: | info:eu-repo/semantics/openAccess