Data/hora: 01/06/2024 17:05:01

Provedor de dados: | 65
País: | Brazil
Título: | Osteoprogenitor cells can enhance early bone formation in critical bone defects in dogs
Autores: | Alves,Endrigo Gabellini Leonel; Serakides,Rogéria; Rosado,Isabel Rodrigues; Paez,Omar Leonardo Aristizabal; Varon,Jéssica Alejandra Castro; Machado,Felipe Nemer; Fukushima,Fabíola Bono; Góes,Alfredo Miranda; Rezende,Cleuza Maria de Faria.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Bone regeneration; Orthopedics; Cellular therapy; Fracture non-union.
Resumo: | ABSTRACT: The aim of this study was to evaluate the effect of osteoprogenitor cells derived from mesenchymal stem cells from adipose tissue (OC-AD-MSCs), and differentiated into osteoblasts, in the treatment of critical bone defects in dogs. Adipose tissue derived mesenchymal stem cells (AD-MSCs) were subjected to osteogenic differentiation for 21 days and used in the treatment of bone defects in dogs radius. Either three experimental groups were bone defects treated with OC-AD-MSCs (OC), defects filled with autogenous bone (Control- C +), or empty defects (Control- C -). Bone regeneration was assessed by radiology, densitometry, and histomorphometry. The area of new bone formation was higher in the OC group compared to the control group (C-) on postoperative day 15. Defects treated with OC-AD-MSCs showed greater neovascularization than the other two groups at 90 days. We concluded that treatment with OC-AD-MSCs increased the area of new bone formation 15 days after surgery; however, it didn’t complete the bone union in critical bone defects in the radius of dogs at 90 days.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000700604
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/0103-8478cr20151109
Formato: | text/html
Fonte: | Ciência Rural  v.47 n.7 2017
Fonte: | info:eu-repo/semantics/openAccess