Data/hora: 08/06/2024 01:44:28

Provedor de dados: | Ciência Rural
País: | Brazil
Título: | Autologous bone marrow transplantation in a dog with lymphoma: a clinical study
Autores: | Cápua,Maria Luísa Buffo de; Coleta,Flávia Eiras Dela; Miotto,Mariana Rodrigues; Calazans,Sabryna Gouveia; Godoy,Aline Vieira; Nakage,Ana Paula Massae; Lisbão,Carolina Bonduki Sales; Daleck,Carlos Roberto; Santana,Aureo Evangelista.
Data: | 2009-04-01
Ano: | 2009
Palavras-chave: | Canine; Cutaneous lymphoma; Autologous bone marrow transplant; Chemotherapy.
Resumo: | The objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. On the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/S0103-84782008005000087
Formato: | text/html
Fonte: | Ciência Rural  v.39 n.2 2009
Fonte: | info:eu-repo/semantics/openAccess