Data/hora: 10/06/2024 17:02:54

Provedor de dados: | Electronic Journal of Biotechnology
País: | Chile
Título: | Diet high in &amp;#945;-linolenic acid up-regulate PPAR-&amp;#945; gene expression in the liver of goats
Autores: | Ebrahimi,Mahdi; Rajion,Mohamed Ali; Meng,Goh Yong; Farjam,Abdoreza Soleimani; Oskoueian,Ehsan; Jafari,Saeid.
Data: | 2015-05-01
Ano: | 2015
Palavras-chave: | Gene expression; Goat; Liver; Omega-3 fatty acid; PPAR.
Resumo: | Background There is little information on the effects of diets containing high &amp;#945;-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high &amp;#945;-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-&amp;#945;) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P &lt; 0.05) up-regulation of PPAR-&amp;#945; gene expression and downregulation of SCD gene in the liver of goats fed the high &amp;#945;-linolenic acid diet. Conclusions In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the &amp;#945;-linolenic acid supplementation in the goat diet. It is suggested that PPAR-&amp;#945; is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000300011
Editor: | Pontificia Universidad Católica de Valparaíso
Formato: | text/html
Fonte: | Electronic Journal of Biotechnology  v.18 n.3 2015