Data/hora: 11/06/2024 10:20:09

Provedor de dados: 	69	
País: 	Chile	
Título: 	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276	
Autores: 	Ramírez,Mario A.; Pérez,Herminia I.; Manjarrez,Norberto; Solís,Aida; Luna,Héctor; Cassani,Julia.	
Data: 	2008-10-01	
Ano: 	2008	
Palavras-chave: 	4-chlorobenzophenone; Biocatalysis; Microbial oxidation; Resolution.	
Resumo: 	Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002	
Editor: 	Pontificia Universidad Católica de Valparaíso	
Formato: 	text/html	
Fonte: 	Electronic Journal of Biotechnology  v.11 n.4 2008