Data/hora: 16/06/2024 10:31:40

Provedor de dados: | 74
País: | Brazil
Título: | Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques
Autores: | Bellini,Marilanda Ferreira; Silva,Ana Elizabete; Varella-Garcia,Marileila.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | CGH; Esophageal carcinoma; FISH; Genomic imbalances; Molecular cytogenetics.
Resumo: | This review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2q, 3q, 5p, 6p, 7, 8q, 9q, 11q, 12p, 14q, 15q, 16, 17, 18p, 19q, 20q, 22q and X, with focal amplifications at 1q32, 2p16-22, 3q25-28, 5p13-15.3, 7p12-22, 7q21-22, 8q23-24.2, 9q34, 10q21, 11p11.2, 11q13, 13q32, 14q13-14, 14q21, 14q31-32, 15q22-26, 17p11.2, 18p11.2-11.3 and 20p11.2. Recurrent losses involved 3p, 4, 5q, 6q, 7q, 8p, 9, 10p, 12p, 13, 14p, 15p, 18, 19p, 20, 22, Xp and Y. Gains at 5p and 7q, and deletions at 4p, 9p, and 11q were significant prognostic factors for patients with ESCC. Gains at 6p and 20p, and losses at 10p and 10q were the most significant imbalances, both in primary carcinoma and in metastases, which suggested that these regions may harbor oncogenes and tumor suppressor genes. Gains at 12p and losses at 3p may be associated with poor relapse-free survival. The clinical applicability of these changes as markers for the diagnosis and prognosis of ESCC, or as molecular targets for personalized therapy should be evaluated.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200001
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572010005000028
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.33 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess