Data/hora: 09/06/2024 17:38:17

Provedor de dados: | Genetics and Molecular Biology
País: | Brazil
Título: | Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
Autores: | Paré,Pamela; Paixão-Côrtes,Vanessa R.; Tovo-Rodrigues,Luciana; Vargas-Pinilla,Pedro; Viscardi,Lucas Henriques; Salzano,Francisco Mauro; Henkes,Luiz E.; Bortolini,Maria Catira.
Data: | 2016-12-01
Ano: | 2016
Palavras-chave: | Oxytocin receptor; Arginine vasopressin receptors; Molecular evolution; Protein disorder; Interaction motifs.
Resumo: | Abstract Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000400646
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2015-0323
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.39 n.4 2016
Fonte: | info:eu-repo/semantics/openAccess