Data/hora: 04/06/2024 02:35:39

Provedor de dados: | 74
País: | Brazil
Título: | Dietary carotenoid-rich oil supplementation improves exercise-induced anisocytosis in runners: influences of haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms in dilutional pseudoanemia ("sports anemia")
Autores: | Miranda-Vilela,Ana L.; Akimoto,Arthur K.; Alves,Penha C.Z.; Pereira,Luiz C.S.; Klautau-Guimarães,Maria N.; Grisolia,Cesar K.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | Caryocar brasiliense Camb hemogram hematimetric indexes (MCV; MCH; MCHC and RDW) haptoglobin antioxidant enzyme polymorphisms.
Resumo: | Physical training induces beneficial adaptation, whereas exhaustive exercises increase reactive oxygen-species generation, thereby causing oxidative damage in plasma and erythrocytes, fractions susceptible to lipid peroxidation. Pequi (Caryocar brasiliense Camb.) is a Brazilian Cerrado fruit containing a carotenoid-rich oil. The aim was to investigate the effects of pequi-oil on exercise-induced oxidative damage in plasma and erythrocytes, after running in the same environment and undergoing weekly training under the same conditions as to type, intensity and length. Evaluations were accomplished after outdoor running on flat land before and after ingestion of 400 mg pequi-oil capsules for 14 days. Blood samples were taken after running and submitted to TBARS assay and erythrogram analysis. Haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms were priorly investigated, so as to estimate genetic influence The reduction in erythrocytes, hemoglobin and hematocrit after pequi-oil treatment was notably associated with higher plasma expansion. Except for MCHC (mean corpuscular hemoglobin concentration) and RDW (red cell distribution width), the results were influenced by the polymorphisms studied. The best response to pequi-oil was presented by MnSOD Val/Val, CAT AA or AT genotypes and the GPX1 Pro allele. The significantly lower RDW and higher MHCH values were related to pequi-oil protective effects. Pequi oil, besides possessing other nutritional properties, showed protective blood effects.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200026
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572010005000022
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.33 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess