Data/hora: 16/06/2024 06:34:51

Provedor de dados: | 74
País: | Brazil
Título: | DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster
Autores: | Silva,Robson Alves da; Dihl,Rafael Rodrigues; Dias,Lucas Pinheiro; Costa,Maiane Papke; Abreu,Bianca Regina Ribas de; Cunha,Kênya Silva; Lehmann,Mauricio.
Data: | 2016-09-01
Ano: | 2016
Palavras-chave: | Antimutagenicity; Cashew apple; Drosophila melanogaster; Honey; Somatic cells.
Resumo: | Abstract Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with the wing spot test in Drosophila melanogaster using co- and post-treatment protocols. Additionally, the antimutagenic activity of two HSCAN components, cashew apple pulp and honey, in MMC-induced DNA damage was also investigated. HSCAN reduced the mutagenic activity of both EMS and MMC in the co-treatment protocol, but had a co-mutagenic effect when post-administered. Similar results were also observed with honey on MMC mutagenic activity. Cashew apple pulp was effective in exerting protective or enhancing effects on the MMC mutagenicity, depending on the administration protocol and concentration used. Overall, these results indicate that HSCAN, cashew apple and honey seem capable of modulating not only the events that precede the induced DNA damages, but also the Drosophila DNA repair processes involved in the correction of EMS and MMC-induced damages.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300431
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-GMB-2015-0129
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.39 n.3 2016
Fonte: | info:eu-repo/semantics/openAccess