Data/hora: 09/06/2024 17:46:48

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Prevalence of common α-thalassemia determinants in south Brazil: importance for the diagnosis of microcytic anemia	
Autores: 	Wagner,Sandrine C.; Castro,Simone M. de; Gonzalez,Tatiana P.; Santin,Ana P.; Filippon,Leticia; Zaleski,Carina F.; Azevedo,Laura A.; Amorin,Bruna; Callegari-Jacques,Sidia M.; Hutz,Mara H.	
Data: 	2010-01-01	
Ano: 	2010	
Palavras-chave: 	Alpha-thalassemia; Brazilian population; Genotype; Hemoglobin; Microcytosis.	
Resumo: 	Alpha thalassemia has not been systematically investigated in Brazil. In this study, 493 unrelated individuals from the southernmost Brazilian state of Rio Grande do Sul were screened for deletional forms of α-thalassemia. One hundred and one individuals had microcytic anemia (MCV &lt; 80 fL) and a normal hemoglobin pattern (Hb A2 &lt; 3.5% and Hb F &lt; 1%). The subjects were screened for -α3.7,-α4.2,-α20.5, -SEA and -MED deletions but only the -α3.7 allele was detected. The -α3.7 allele frequency in Brazilians of European and African ancestry was 0.02 and 0.12, respectively, whereas in individuals with microcytosis the frequency was 0.20. The prevalence of α-thalassemia was significantly higher in individuals with microcytosis than in healthy individuals (p = 0.001), regardless of their ethnic origin. There were also significant differences in the hematological parameters of individuals with -α3.7/αα, -α3.7/α3.7 and β-thalassemia trait compared to healthy subjects. These data suggest that α-thalassemia is an important cause of microcytosis and mild anemia in Brazilians.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400008	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572010005000086	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.33 n.4 2010	
Fonte: 	info:eu-repo/semantics/openAccess