Data/hora: 02/06/2024 02:21:26

Provedor de dados: | 74
País: | Brazil
Título: | Prevalence of common α-thalassemia determinants in south Brazil: importance for the diagnosis of microcytic anemia
Autores: | Wagner,Sandrine C.; Castro,Simone M. de; Gonzalez,Tatiana P.; Santin,Ana P.; Filippon,Leticia; Zaleski,Carina F.; Azevedo,Laura A.; Amorin,Bruna; Callegari-Jacques,Sidia M.; Hutz,Mara H.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | Alpha-thalassemia; Brazilian population; Genotype; Hemoglobin; Microcytosis.
Resumo: | Alpha thalassemia has not been systematically investigated in Brazil. In this study, 493 unrelated individuals from the southernmost Brazilian state of Rio Grande do Sul were screened for deletional forms of α-thalassemia. One hundred and one individuals had microcytic anemia (MCV &lt; 80 fL) and a normal hemoglobin pattern (Hb A2 &lt; 3.5% and Hb F &lt; 1%). The subjects were screened for -α3.7,-α4.2,-α20.5, -SEA and -MED deletions but only the -α3.7 allele was detected. The -α3.7 allele frequency in Brazilians of European and African ancestry was 0.02 and 0.12, respectively, whereas in individuals with microcytosis the frequency was 0.20. The prevalence of α-thalassemia was significantly higher in individuals with microcytosis than in healthy individuals (p = 0.001), regardless of their ethnic origin. There were also significant differences in the hematological parameters of individuals with -α3.7/αα, -α3.7/α3.7 and β-thalassemia trait compared to healthy subjects. These data suggest that α-thalassemia is an important cause of microcytosis and mild anemia in Brazilians.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400008
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572010005000086
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.33 n.4 2010
Fonte: | info:eu-repo/semantics/openAccess