Data/hora: 10/06/2024 08:21:55

Provedor de dados: | Genetics and Molecular Biology
País: | Brazil
Título: | Protective effect of Hemidesmus indicus R.Br. root extract against cisplatin-induced cytogenetic damage in mouse bone marrow cells
Autores: | Ananthi,Rajagopal; Chandra,Nallathambi; Santhiya,Sathiyavedu T.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | Genoprotective; Cytotoxic; Chromosomal aberrations; Micronucleus; Mitotic index.
Resumo: | The aqueous extract of Hemidesmus indicus roots was investigated for its in vivo antigenotoxic effect against cisplatin-induced cytogenetic damage. Swiss albino mice were administered with various doses of the extract either singly (50, 100 and 200 mg/kg body weight) or as split doses (10, 20 and 40 mg/kg bw/day) for five consecutive days by oral gavage. As endpoints, chromosome aberrations, micronuclei in polychromatic erythrocytes, mitotic index and PCE/NCE ratio were estimated. The extract protected the bone marrow cells from cisplatin-induced genotoxicity in an inverse dose-dependent manner. However, the extract was cytotoxic at all doses. But, under split dose regime it conferred a higher level of genoprotection and was not cytotoxic at the lower two doses. The presence of saponins, tannins, phenols, terpenoids, flavonoids and coumarins in the crude extract could explain these effects.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000100030
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572010005000011
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.33 n.1 2010
Fonte: | info:eu-repo/semantics/openAccess