Data/hora: 08/06/2024 14:45:27

Provedor de dados: | 74
País: | Brazil
Título: | A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
Autores: | Annichino-Bizzacchi,Joyce M.; Pugliese,Luciana; Arruda,Valder R.
Data: | 1998-09-01
Ano: | 1998
Resumo: | Plasminogen activator inhibitor-1 (PAI-1) is an important inhibitor of fibrinolysis, and increased levels of PAI-1 are associated with atheroma and myocardial infarction. A common 4G/5G insertion/deletion polymorphism located in the promoter region of PAI-1 gene has been described associated with PAI-1 activity in plasma levels. Genotyping of this polymorphism is commonly conducted with an allele-specific oligonucleotide melting technique. In the present study, we describe a quick, easy method for genotyping 4G/5G polymorphism in the promoter region of the PAI-1 gene.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300004
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47571998000300004
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.21 n.3 1998
Fonte: | info:eu-repo/semantics/openAccess