Data/hora: 02/06/2024 02:48:32

Provedor de dados: | 74
País: | Brazil
Título: | New evidence for balancing selection at the HLA-G locus in South Amerindians
Autores: | Veit,Tiago Degani; Cazarolli,Juciana; Salzano,Francisco Mauro; Schiengold,Marion; Chies,José Artur Bogo.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | HLA-G 14 bp INDEL; Balancing selection; Amerindians; Pathogen resistance.
Resumo: | HLA-G is a non-classical HLA (Human Leukocyte Antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both DNA and protein levels. Several studies suggest that HLA-G could play a role, as an immunoregulatory molecule, in situations as diverse as transplantation, cancer, viral infections and inflammatory diseases. A total of 237 individuals from 21 South American tribes speaking nine different linguistic families were studied in relation to the 14 bp insertion/deletion polymorphism at the HLA-G gene. A consistent (seven in nine) excess of heterozygosity in samples classified by language was obtained. Our data supply evidences for balancing selection acting at the HLA-G 14 bp INDEL region. Enhanced fetal survival in a pathogen-rich environment may account for these findings.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600005
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572012000600005
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.35 n.4 suppl.1 2012
Fonte: | info:eu-repo/semantics/openAccess