Data/hora: 17/06/2024 14:49:32

Provedor de dados: | 74
País: | Brazil
Título: | Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro
Autores: | Bellagamba,Bruno Corrêa; Abreu,Bianca Regina Ribas de; Grivicich,Ivana; Markarian,Carolina Franke; Chem,Eduardo; Camassola,Melissa; Nardi,Nance Beyer; Dihl,Rafael Rodrigues.
Data: | 2016-03-01
Ano: | 2016
Palavras-chave: | Mesenchymal stem cells; Cisplatin; MTT; Comet assay; OVCAR-3 cells.
Resumo: | Abstract Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000100129
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-GMB-2015-0057
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.39 n.1 2016
Fonte: | info:eu-repo/semantics/openAccess