Data/hora: 09/06/2024 02:51:14

Provedor de dados: | 74
País: | Brazil
Título: | Chemical composition and antigenotoxic properties of Lippia alba essential oils
Autores: | López,Molkary Andrea; Stashenko,Elena E.; Fuentes,Jorge Luis.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Lippia alba; Essential oil; Antigenotoxicity; Bleomycin; SOS chromotest.
Resumo: | The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral (33% geranial and 25% neral), geraniol (7%) and trans-β-caryophyllene (7%) for L. alba specimen COL512077, and carvone (38%), limonene (33%) and bicyclosesquiphellandrene (8%) for the other, COL512078. The genotoxicity and antigenotoxicity of EO and the compounds citral, carvone and limonene, were assayed using the SOS Chromotest in Escherichia coli. The EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene) showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300019
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572011005000030
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.34 n.3 2011
Fonte: | info:eu-repo/semantics/openAccess