Data/hora: 10/06/2024 01:12:10

Provedor de dados: | 74
País: | Brazil
Título: | Vegetable and fruit juice enhances antioxidant capacity and regulates antioxidant gene expression in rat liver, brain and colon
Autores: | Yuan,Linhong; Liu,Jinmeng; Zhen,Jie; Xu,Yao; Chen,Shuying; Halm-Lutterodt,Nicholas Van; Xiao,Rong.
Data: | 2017-03-01
Ano: | 2017
Palavras-chave: | Antioxidant; Biomarkers; Fruit and vegetable; Gene expression.
Resumo: | Abstract To explore the effect of fruit and vegetable (FV) juice on biomarkers of oxidative damage and antioxidant gene expression in rats, 36 adult male Wistar rats were randomly divided into control, low FV juice dosage or high FV juice dosage treatment groups. The rats were given freshly extracted FV juice or the same volume of saline water daily for five weeks. After intervention, serum and tissues specimens were collected for biomarker and gene expression measurement. FV juice intervention increased total antioxidant capacity, glutathione, vitamin C, β-carotene, total polyphenols, flavonoids levels andglutathione peroxidaseenzyme activity in rat serum or tissues (p &lt; 0.05). FV juice intervention caused reduction of malondialdehyde levels in rat liver (p &lt; 0.05) and significantly modulated transcript levels of glutamate cysteine ligase catalytic subunit (GCLC) and NAD(P)H:quinone oxidoreductase l (NQO1)in rat liver and brain (p &lt; 0.05). The results underline the potential of FV juice to improve the antioxidant capacity and to prevent the oxidative damage in liver, brain and colon.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100134
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2016-0159
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.40 n.1 2017
Fonte: | info:eu-repo/semantics/openAccess