Data/hora: 11/06/2024 10:20:06

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population	
Autores: 	Lima,Magaly B.P.L.V.; Oliveira-Filho,Aldemir Branco de; Campos,Júlia F.; Melo,Fárida C.B.C.; Neves,Washington Batista das; Melo,Raul Antônio Morais; Lemos,José Alexandre Rodrigues.	
Data: 	2009-01-01	
Ano: 	2009	
Palavras-chave: 	ABO blood group; Factor V Leiden; Venous thrombosis.	
Resumo: 	Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200010	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572009000200010	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.32 n.2 2009	
Fonte: 	info:eu-repo/semantics/openAccess