Data/hora: 02/06/2024 00:45:15

Provedor de dados: 	74	
País: 	Brazil	
Título: 	CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry	
Autores: 	Carvalho,Mônica W.P.; Leboute,Ana P.M.; Oliveira,Silviene F.; Sousa,Sandra M.B.; Klautau-Guimarães,Maria de Nazaré; Simões,Aguinaldo L.	
Data: 	2004-01-01	
Ano: 	2004	
Palavras-chave: 	CCR5; Genetic polymorphism; Sub-Saharan Afro-derived Brazilian populations; Ethnic-grouspecific marker.	
Resumo: 	This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6%) than that found in the Rio das Rãs (1%) and São Gonçalo (0.9%) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300002	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572004000300002	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.27 n.3 2004	
Fonte: 	info:eu-repo/semantics/openAccess