Data/hora: 09/06/2024 09:18:26

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	ANRIL rs1333049 C/G polymorphism and coronary artery disease in a North Indian population - Gender and age specific associations	
Autores: 	Kaur,Naindeep; Singh,Jagtar; Reddy,Sreenivas.	
Data: 	2020-01-01	
Ano: 	2020	
Palavras-chave: 	Genetic polymorphism; Coronary artery disease; North Indian Population; ARMS-PCR; Epidemiology study.	
Resumo: 	Abstract Many studies conducted worldwide substantiate a role of genetic polymorphisms in non-coding regions linked with coronary artery disease (CAD). One such single nucleotide polymorphism (SNP) of a non-coding RNA in the INK4 locus (ANRIL) i.e. rs1333049 C/G in the vicinity of cell cycle regulating genes is documented to have a role in CAD risk. In this study we aimed to determine the association of ANRIL rs1333049 C/G with CAD in a North Indian population. Five hundred disease free controls and 500 CAD patients were genotyped using allele specific ARMS-PCR method. High risk association of rs1333049 was seen in both heterozygous and mutant genotypes (OR=2.883, 95% CI=1.475-5.638 and p=0.002 and OR=6.717, 95% CI=3.444-13.102 and p &lt; 0.001 respectively). Gender stratified analysis revealed risk association in both heterozygous and mutant genotypes in males. However, risk association in the mutant genotype and females was documented. Similarly, risk association was seen in subjects above 40 years of age in heterozygous and mutant genotypes. Similarly, risk association was reported in obese, sedentary lifestyle, positive family history and smoking in the heterozygous and mutant genotype and with diabetes in the mutant GG genotype. The study revealed high risk association of ANRIL rs1333049 with CAD and other risk factors.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100114	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2019-0024	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.43 n.1 2020	
Fonte: 	info:eu-repo/semantics/openAccess