Data/hora: 06/06/2024 05:55:07

Provedor de dados: | 74
País: | Brazil
Título: | Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon
Autores: | Oliveira,Haiala S. Silva de; Silva,Aylla N. Lima Martins da; Andrade,Gabriela Barreto; Gaia,Karoline Coelho; Costa,Greice de Lemos Cardoso; Santos,Ândrea K. Campos Ribeiro dos; Guerreiro,João Farias.
Data: | 2018-12-01
Ano: | 2018
Palavras-chave: | G6PD mutations; Duffy blood group; Afro-descendants; Brazilian Amazon.
Resumo: | Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY*B and FY*BES) were investigated in an Afro-descendant population from state of Pará, Brazilian Amazon. G6PD variants and Duffy blood group alleles were determined by TaqMan SNP genotyping assay. Overall, molecular genotyping revealed the presence of G6PD variants in 126 (24%) of the individuals studied (5% male and 19% female), and frequencies of the G6PD*A- and G6PD*A alleles were 0.061 and 0.104, respectively. Duffy blood group genotyping showed that 24.3% of people were Duffy-negative and 41.3% were heterozygous for FY*BES. The frequency of allele FY*BES was 41.0%. The results emphasize the need to monitor G6PD deficiency for the use of primaquine in the routine care of the Afro-descendant communities of the Trombetas, Erepecuru and Cumná rivers, evaluating the risks of hemolytic crisis in case of recurrence of malaria in the region. In addition, the possible greater protection against malaria conferred by these erythrocyte polymorphisms deserves to be better investigated and explored among these Afro-descendants.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500758
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2017-0253
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.41 n.4 2018
Fonte: | info:eu-repo/semantics/openAccess