Data/hora: 10/06/2024 05:26:09

Provedor de dados: | 74
País: | Brazil
Título: | Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
Autores: | Hsieh,Yao-Yuan; Chang,Chi-Chen; Tsai,Fuu-Jen; Peng,Ching-Tien; Yeh,Lian-Shun; Lin,Cheng-Chieh.
Data: | 2004-01-01
Ano: | 2004
Palavras-chave: | Endometriosis; Insulin-like growth factor; IGF-2.
Resumo: | Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200006
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572004000200006
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.27 n.2 2004
Fonte: | info:eu-repo/semantics/openAccess