Data/hora: 18/06/2024 18:20:18

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients	
Autores: 	Osman,Emad-Aldin I.; Hamad,Kamal; Elmula,Imad M. Fadl; Ibrahim,Muntaser E.	
Data: 	2010-01-01	
Ano: 	2010	
Palavras-chave: 	BCR-ABL; Chronic myeloid leukemia; Ph chromosome; Sudanese; RT-PCR.	
Resumo: 	The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572010005000037	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.33 n.2 2010	
Fonte: 	info:eu-repo/semantics/openAccess