Data/hora: 04/06/2024 00:23:45

Provedor de dados: | 74
País: | Brazil
Título: | Myeloperoxidase gene-463G &gt; a polymorphism and premature coronary artery disease
Autores: | Zhong,Chen; Quanzhong,Yin; Genshan,Ma; Hua,Zhang; Ruolong,Zheng; Jiahong,Wang; Chunheng,Gao.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | Premature coronary artery disease; Myeloperoxidase; Protective genetic polymorphism.
Resumo: | We investigated the association between myeloperoxidase gene -463G &gt; A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p &lt; 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G &gt; A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572009005000035
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.32 n.2 2009
Fonte: | info:eu-repo/semantics/openAccess