Data/hora: 16/06/2024 06:16:15

Provedor de dados: 	74	
País: 	Brazil	
Título: 	[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma	
Autores: 	Shi,Lixin; Zhang,Lei; Wang,Chunyang; Sun,Shengkun; Cao,Xiyuan; Zhang,Xu.	
Data: 	2017-06-01	
Ano: 	2017	
Palavras-chave: 	Renal cell carcinoma; MicroRNA 378; Diagnosis; Patients; AUC.	
Resumo: 	Abstract Studies have demonstrated that miRNA-378 is expressed in various malignant tumors. In the present study, we aimed to explore the expression of serum miRNA-378 and its clinical significance in renal cell carcinoma (RCC) patients. A total of 75 RCC patients, 63 renal cysts (RC) patients and 75 healthy controls were selected. The miRNA-378 level in RCC and RC groups was significantly higher than in healthy control group, with RCC group having the highest level. The miRNA-378 levels were significantly decreased within the same group after surgery. When compared with healthy controls, RC group had higher levels but not significantly (p &gt; 0.05) while levels in RCC group were significantly higher (p &lt; 0.05). miRNA-378 expression was correlated with clinical stage and differentiation degree, but not correlated with patient's age, gender, surgical strategy and tumor diameter. The AUC of miRNA-378 was 0.896, 95% confidence interval was 0.847 to 0.945, and AUC hypothesis testing was statistically significant (p &lt; 0.001, RCC vs healthy control). miRNA-378 shows potential in the diagnosis and prediction of postoperative curative effect of renal cell carcinoma, but further studies with lager samples are needed.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300525	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2016-0121	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.40 n.2 2017	
Fonte: 	info:eu-repo/semantics/openAccess