Data/hora: 17/06/2024 14:31:40

Provedor de dados: 	74	
País: 	Brazil	
Título: 	ADP-ribosylation: from molecular mechanisms to human disease	
Autores: 	Hoch,Nicolas C.; Polo,Luis M.	
Data: 	2020-01-01	
Ano: 	2020	
Palavras-chave: 	ADP ribose; PARP; DNA damage response; DNA repair; Parthanatos.	
Resumo: 	Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2019-0075	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.43 n.1 suppl.1 2020	
Fonte: 	info:eu-repo/semantics/openAccess