Data/hora: 10/06/2024 17:11:47

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	Polymorphism of the catechol-O-methyltransferase gene   in Han Chinese patients with psoriasis vulgaris	
Autores: 	Gao,Lin; Gao,Lin; Li,Hong; Li,Hong; Li,Kai; Li,Kai; Shen,Zhu; Liu,Ling; Li,Chunying; Zhang,Zhengdong; Liu,Yufeng.	
Data: 	2009-01-01	
Ano: 	2009	
Palavras-chave: 	COMT; Gene polymorphism; Genetic susceptibility; Psoriasis.	
Resumo: 	Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT )  158  polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that the  COMT-158  G  &gt;  A  polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied.  COMT-158 G  &gt;  A  polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between the  COMT-158  allele  A  and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that the  COMT-158 G  &gt;  A  polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100005	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572009005000002	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.32 n.1 2009	
Fonte: 	info:eu-repo/semantics/openAccess