Data/hora: 02/06/2024 02:23:54

Provedor de dados: | 74
País: | Brazil
Título: | Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1)
Autores: | Zhu,Xiang-Yu; Liu,Ning; Liu,Wei; Song,Shao-Wei; Guo,Ke-Jian.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | E-cadherin; Epithelial-mesenchymal transition (EMT); Integrin-linked kinase (ILK); Panc-1 cell line; RNA interference (RNAi).
Resumo: | Integrin-linked kinase (ILK) is an ankyrin repeat-containing serine-threonine protein kinase that is involved in the regulation of integrin-mediated processes such as cancer cell proliferation, migration and invasion. In this study, we examined the effect of a lentivirus-mediated knockdown of ILK on the proliferation, migration and invasion of pancreatic cancer (Panc-1) cells. Immunohistochemical staining showed that ILK expression was enhanced in pancreatic cancer tissue. The silencing of ILK in human Panc-1 cells led to cell cycle arrest in the G0/G1 phase and delayed cell proliferation, in addition to down-regulating cell migration and invasion. The latter effects were mediated by up-regulating the expression of E-cadherin, a key protein in cell adhesion. These findings indicate that ILK may be a new diagnostic marker for pancreatic cancer and that silencing ILK could be a potentially useful therapeutic approach for treating pancreatic cancer.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300022
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572012005000028
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.35 n.2 2012
Fonte: | info:eu-repo/semantics/openAccess