Data/hora: 02/06/2024 07:43:35

Provedor de dados: | 74
País: | Brazil
Título: | Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
Autores: | Otero,Luize; Souza,Daiane Correa de; Tavares,Rita de Cássia; Gomes,Bernadete Evangelho; Padilha,Telma França; Bouzas,Luiz Fernando; Fernandez,Teresa de Souza; Abdelhay,Eliana.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | Monosomy 7; Donor cell leukemia; Bone marrow transplantation; Severe aplastic anemia.
Resumo: | Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572012005000056
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.35 n.4 2012
Fonte: | info:eu-repo/semantics/openAccess