Data/hora: 16/06/2024 04:48:06

Provedor de dados: 	74	
País: 	Brazil	
Título: 	NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus	
Autores: 	Natarajan,Satheesh.	
Data: 	2010-01-01	
Ano: 	2010	
Palavras-chave: 	Antiviral inhibitor; Drug discovery; Multifunctional protein; NS3; Protease.	
Resumo: 	The development of novel therapeutic agents is essential for combating the increasing number of cases of dengue fever in endemic countries and among a large number of travelers from non-endemic countries. The dengue virus has three structural proteins and seven non-structural (NS) proteins. NS3 is a multifunctional protein with an N-terminal protease domain (NS3pro) that is responsible for proteolytic processing of the viral polyprotein, and a C-terminal region that contains an RNA triphosphatase, RNA helicase and RNA-stimulated NTPase domain that are essential for RNA replication. The serine protease domain of NS3 plays a central role in the replicative cycle of dengue virus. This review discusses the recent structural and biological studies on the NS2B-NS3 protease-helicase and considers the prospects for the development of small molecules as antiviral drugs to target this fascinating, multifunctional protein.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200002	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572010000200002	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.33 n.2 2010	
Fonte: 	info:eu-repo/semantics/openAccess