Data/hora: 13/06/2024 23:47:23

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Absence of TERT promoter mutations in colorectal precursor lesions and cancer	
Autores: 	Cruvinel-Carloni,Adriana; Yamane,Letícia; Scapulatempo-Neto,Cristovam; Guimarães,Denise; Reis,Rui Manuel.	
Data: 	2018-03-01	
Ano: 	2018	
Palavras-chave: 	Colorectal carcinoma; TERT promoter mutations; Precursor lesions.	
Resumo: 	Abstract Hotspot mutations (c.-124bp G &gt; A and c.-146bp G &gt; A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian patients, including 103 subjects with precursor lesions and 42 with colorectal carcinomas, and we associated the presence of such mutations with the patients clinical-pathological features. The mutation analysis was conclusive in 123 cases, and none of the precursor and colorectal carcinoma cases showed TERT promoter mutations. We conclude that TERT mutations are not a driving factor in colorectal carcinogenesis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000100082	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2017-0133	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.41 n.1 2018	
Fonte: 	info:eu-repo/semantics/openAccess