Data/hora: 01/06/2024 02:47:25

Provedor de dados: | Genetics and Molecular Biology
País: | Brazil
Título: | Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses
Autores: | Silva,Aline Correa da; Brass,Karin Erica; Loreto,Elgion da Silva; Vinocur,Myriam Elizabeth; Pozzobon,Ricardo; Azevedo,Marcos da Silva.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Horse; Respiratory disease; SSCP; Alpha-1-antitrypsin; Serpin.
Resumo: | The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300015
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572011005000017
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.34 n.3 2011
Fonte: | info:eu-repo/semantics/openAccess