Data/hora: 01/06/2024 18:30:44

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children	
Autores: 	Melo,Silvia V.; Agnes,Grasiela; Vitolo,Márcia R.; Mattevi,Vanessa S.; Campagnolo,Paula D.B.; Almeida,Silvana.	
Data: 	2017-06-01	
Ano: 	2017	
Palavras-chave: 	Food intake; Polymorphism; TAS1R2 gene; TAS1R3 gene; Taste receptors.	
Resumo: 	Abstract Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method. Food intake and nutritional status were compared among individuals with different single nucleotide polymorphism (SNP) genotypes. At 3.9 years old, children homozygous (Val/Val) for the TAS1R2 Ile191Val polymorphism ingested less sugar and sugar-dense foods than children who were *Ile carriers. This finding demonstrated that a genetic variant of the T1R2 taste receptor is associated with the intake of different amounts of high sugar-content foods in childhood. This association may provide new perspectives for studying dietary patterns and nutritional status in childhood.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300415	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2016-0205	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.40 n.2 2017	
Fonte: 	info:eu-repo/semantics/openAccess