Data/hora: 02/06/2024 10:57:09

Provedor de dados: | Genetics and Molecular Biology
País: | Brazil
Título: | Differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis
Autores: | Garcia-Hernandez,Samanta Celeste; Meneses-Sanchez,Perla; Porchia,Leonardo Martin; Torres-Rasgado,Enrique; Pérez-Fuentes,Ricardo; Gonzalez-Mejia,Martha Elba.
Data: | 2019-09-01
Ano: | 2019
Palavras-chave: | MTHFR; Protective factor; Latin America; Leukemia.
Resumo: | Abstract Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos. PubMed, SCOPUS, EBSCO, LILACS, and other Latin-specific databases were searched for case-control studies that investigated the association between these polymorphisms and hematologic malignancies until November 2017. Genotype distributions were extracted and either fixed-effects or random-effects models were used to calculate the pooled crude odds ratios (ORs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg-Mazumdar’s test and Egger’s test. From 290 publications, we identified 15 studies on the C677T polymorphism and 13 studies on the A1298C polymorphism. We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p&lt;0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p&lt;0.05) in developing ALL for all genetic models. No associations were determined for CML, AML, or MM for either polymorphism. This meta-analysis demonstrated that the A1298C polymorphism was associated with an increased risk of developing ALL, whereas the C677T polymorphism was associated with a decreased risk (protective factor) in the Latino population.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000400549
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2018-0161
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.42 n.3 2019
Fonte: | info:eu-repo/semantics/openAccess