Data/hora: 04/06/2024 01:46:42

Provedor de dados: | 74
País: | Brazil
Título: | Molecular characterization of MHC-DRB cDNA in water buffalo (Bubalus bubalis)
Autores: | Naskar,Soumen; Deb,Sitangsu M.; Niranjan,Saket K.; Kumar,Subodh; Sharma,Deepak; Sakaram,Durgam; Sharma,Arjava.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | Water buffalo; CDNA; DRB; MHC; Phylogeny.
Resumo: | In the present study, water buffalo MHC (Bubu)-DRB cDNA was cloned and characterized. The 1022 base long-amplified cDNA product encompassed a single open reading frame of 801 bases that coded for 266 amino acids. The Bubu-DRB sequence showed maximum homology with the BoLA-DRB3*0101 allele of cattle. A total of seven amino acid residues were found to be unique for the Bubu-DRB sequence. The majority of amino acid substitutions was observed in the β1 domain. Residues associated with important functions were mostly conserved. Water buffalo DRB was phylogenetically closer to goat DRB*A.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100013
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572012005000013
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.35 n.1 2012
Fonte: | info:eu-repo/semantics/openAccess