Data/hora: 10/06/2024 11:08:35

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster	
Autores: 	Pereira,Denise G.; Antunes,Lusânia M.G.; Graf,Ulrich; Spanó,Mário A.	
Data: 	2008-12-01	
Ano: 	2008	
Palavras-chave: 	Antigenotoxicity; SMART; Wing spot test.	
Resumo: 	Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. ginseng (2.5, 5.0 or 10.0 mg/mL) and its ability to protect against the genotoxicity of doxorubicin (DOX; 0.125 mg/mL) by using the Drosophila melanogaster wing somatic mutation and recombination test (SMART) with standard and high-bioactivation crosses of flies. Panax ginseng was not genotoxic at the concentrations tested, whereas DOX-induced genotoxicity in marker-heterozygous flies resulted mainly from mitotic recombination. At low concentrations, P. ginseng had antirecombinogenic activity that was independent of the concentration of extract used. Recombination events may promote cancer, but little is known about the ability of P. ginseng to inhibit such recombination or modulate DNA repair mechanisms.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500024	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572008000500024	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.31 n.4 2008	
Fonte: 	info:eu-repo/semantics/openAccess