Data/hora: 10/06/2024 03:33:12

Provedor de dados: 	74	
País: 	Brazil	
Título: 	CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population	
Autores: 	Coura,Renata dos Santos; Marques,Christiane de Fátima Silva; Koifman,Rosalina J.; Koifman,Sergio; Cabello,Pedro Hernan; Hatagima,Ana.	
Data: 	2007-01-01	
Ano: 	2007	
Palavras-chave: 	Cytochromes P450; CYP1A1; CYP2E1; Brazil.	
Resumo: 	The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572007000100001	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.30 n.1 2007	
Fonte: 	info:eu-repo/semantics/openAccess